IV: ADULT ACUTE NONLYMPHOCYTIC LEUKAEMIA:30-40mg/m2/day on days 123 of first course & on days 1,2 of subsequent courses. Drug coadministered with Cytosine Arabinoside 100mg/m2/day by IV infusion for 7 days for first course & for 5 days for subsequent courses. Courses may be repqeated at 3-6 weeks intervals. Cummulative dose should not exceed 550mg/m2.
IV: ADULT LYMPHOCYTIC LEUKAEMIA:45mg/m2/day on days 1,2,3, the drug coadministered with Vincristine 2mg by IV on days 1,8 & 15 + Prednisone 40mg/m2/day orally on days 1 through 22, then tapered between days 22 & 29 + L-asparginase 500IU/kg/day for 10 days, IV on days 22 through 32.
KAPOSIS SARCOMA:40mg/m2 every 2 weeks. |